ABSTRACTS XVI ALASBIMN CONGRESS  NUCLEAR MEDICINE 1999.

15. PERIPHERAL VASCULAR DISEASE

Margarida Rodriguez, H. Sinzinger

Dept. of Nuclear Medicine, University of Vienna, Austria

margarida.rodrigues@ahh-wien.ac.at

The radiolabeling of platelets and various white blood cell elements has been approached in atherosclerosis with differing success. In particular, there is increasing evidence that atherosclerosis has a significant inflammatory component. Radiolabeling of autologous lymphocytes was not successful in identifying any of the human lesions examined. Isolation and radiolabeling of autologous monocytes with ¹¹¹ In-oxine with and without cellular preloading with radiolabeled oxidatively modified low-density lipoproteins was able to show some lesions, however, the isolation and preparation procedure, the radiation sensivity of the cells resulting in severe cellular damage and the available numbre or cells was limiting the success, therefore decreasing the value of clinical applicability of this methodology. White blood cell labeling with controlled lesions, however ¹¹¹ In-oxine and ^99mTc-oxine as well ^99mTc-HMPAO was atempted. The sensitivity as compared to ultrasonographically controlled lesions, however was very low in a range of about 60% only. In contraste, the radiolabeling of platelets was much more successfully attempted in order to identify lesions as to there thrombogenicity, platelet deposition, clinical stage and influence on the kinetic behaviour of platelets. The most promising date were reported when using this technique to assess therapeutic efficacy of drugs. The results using various radiolabeled blood cellular components to image the atherosclerotic process is still very limited. This approach allows to obtain a detailed insight into the biochemical and functional aspects at the local level, however, without allowing any specific information as to the extent or the stage of the lesion.

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