Abstracts XIX Brazilian Congress of Nuclear Medicine

9. PET/SPECT

In addition to a qualitative evaluation, quantitative data of functional (FDG-PET) and morphologic (MRI) imaging were obtained to evaluate a potential correlation between the degree of mesial temporal sclerosis (MTS) and the temporal metabolism. In 33 patients with partial epilepsy (mean age 31.5 yrs., range 8-53 yrs., m:f = 16:17) FDG-PET imaging (Siemens/CTI, ECAT EXACT) including a SUV-analysis of the hippocampus, ncl. amygdalae, and the temporopolar, -basal and -lateral neocortical structures was done as well as a MRI study (Philips Gyroscan ACS II, 1.5 T) including a coronal T2w TSE (THK 2 mm) for volumetry and a coronal sequence for T2-relaxometry (THK 5 mm). Mean hippocampal volume was 2.12 ml +/- 0.59 for diseased hippocampi and 2.62 +/- 0.4 for the healthy side (normal range 1.9 - 3.0 ml). Mean T2-relaxometry was 117.7 ms and 107.9 ms (normal < 114 ms). In contrast, mean SUV within the hippocampus was 3.7 +/- 0.74 (side of seizure onset) and 3.79 +/- 0.79 (healthy side). Spearman's correlation of the quantitative results showed no positive or negative correlation. In conclusion, these data underline the relative independence of morphologic and functional information and furthermore the value of metabolic imaging as a measure of cortical dysfunction and anomalies which can clarify the extent of diseased cortex and also detect an epileptogenic focus / region even in morphologically normal subjects.

1.Cardiology |  2.Endocrinology | 3.Equipment: Quality Control | 4.Gastroenterology |  5.Infectious Diseases |  6.Nephro-Urology |  7.Oncology |  8.Orthopheadics | 9.PET/SPECT | 10.Pneumology |  11.Radiobiology |  12.Radiopharmacy |  13.Special Clinical Applications |  14.Neuropsychiatry |