Abstracts XIX Brazilian Congress of Nuclear Medicine

5. INFECTIOUS DISEASES

Paracoccidioidomycosis is a disease caused by the dimorphic fungus P. brasiliensis.. The disease spreads from Mexico to Argentina and is the only deep fungal infection restricted to Latin America. Diagnosis is made by demonstration of P. brasiliensis in the tissues or body fluids. Gallium-67 whole body scintigraphy, although not routinely used, is useful in the detection of sites of infection and for monitoring the activity of the disease. We report on a 26 year-old female, admitted with abdominal pain, fever and weight loss. Clinical and laboratory investigation established the diagnosis of paracoccidioidomycosis. Inspite of treatment, the patient evolved with complications which led to her death. During the course of the disease, sequential gallium-67 whole body scintigraphies were performed. The initial gallium-67 study revealed increased tracer accumulation in the abdomen and right posterior cervical lymph nodes. A second study performed one year later revealed diffuse lung accumulation and the abdominal concentration persisted. There was also abnormal accumulation in the kidneys and breasts interpreted as anfotericin B nephrotoxicity and prolonged stimulation of parenchymal breast tissue by metoclopramida. Two other gallium-67 whole body scintigraphies showed persistent abdominal and lung accumulation secondary to blastomycosis. The scintigraphic findings correlated well with the clinical history and evolution.

1.Cardiology |  2.Endocrinology | 3.Equipment: Quality Control | 4.Gastroenterology |  5.Infectious Diseases |  6.Nephro-Urology |  7.Oncology |  8.Orthopheadics | 9.PET/SPECT | 10.Pneumology |  11.Radiobiology |  12.Radiopharmacy |  13.Special Clinical Applications |  14.Neuropsychiatry |