ABSTRACTS PRESENTADOS AL 11th INTERNATIONAL SYMPOSIUM "RADIONUCLIDES IN NEPHRO-UROLOGY", REALIZADO EN MONTEREY, CALIFORNIA, 13-17 MAYO 2001.

7. PATIENTS WITH ADVANCED OVARIAN CANCER HAVE ELEVATED 51CrEDTA PLASMA CLEARANCE EARLY POSTOPERATIVELY.

S. S. Nielsen, H. Havsteen, L. K. Petersen, L. E. Nielsen, M. Rehling.
Dept's. of Clinical Physiology and Nuclear Medicine, Oncology and Gynaecology, Aarhus University Hospital, Aarhus, Denmark.

We have observed that patients with advanced ovarian cancer have elevated 51 Cr-EDTA plasma clearance (Clp-EDTA) measured early postoperatively compared to late. To examine if this observation reflects a true difference, we retrospectively studied patients with ovarian cancer and Clp-EDTA measured early postoperatively (early group) and a control group of patients with ovarian cancer and Clp-EDTA measured just before chemotherapy (late group). We obtained the following results (mean ± SEM)

The early Clp-EDTA was significantly higher than the late Clp-EDTA. Twelve patients (46°/) in the early group had GFR values above upper normal limits. Only five patients (18%) in the late group had GFR values above upper normal limits. The early and late group were comparable regarding age, tumour histology and cancer stages. The elevated Clp-EDTA values were not correlated lo the amount of ascited removed by operation.
We conclude that patients with advanced ovarian cancer have significantly higher 51 Cr-EDTA plasma clearance in the early postoperative phase than compared with similar patients with 51Cr-EDTA measured late postoperatively. Whether this is due to a temporarily elevated GFR in patients operated for ovarian cancer or due to extrarenal clearance of 51Cr-EDTA postoperatively is presently undetermined. The observation has, never the less, major clinical significance when 51Cr-EDTA plasma clearance is used to calculate the intended dose of chemotherapy.