ABSTRACTS PRESENTADOS AL 11th INTERNATIONAL SYMPOSIUM "RADIONUCLIDES IN NEPHRO-UROLOGY", REALIZADO EN MONTEREY, CALIFORNIA, 13-17 MAYO 2001.

Miyazaki C., Katoh N., Abo D., Ohyama N., Kubo K., Harada H. Hirano T. Sapporo.

City General Hospital, Japan.

chihomiy@jaz.so-net.ne.jp

It is known that patients with renal transplant generally exhibit reduced bone mass. We evaluated bone mineral density (L2-L4 frontal and lateral lumbar spine) measured before and after renal transplantation using dual-energy X-ray absorptiometry (DXA. Hologic QDR 2000).

Twenty-eight males and 17 females (mean age 36.6±1.09 y.o. 33.7±8.1 y.o.) were studied. The initial bone mineral density (BMD) was measured within one month before transplantation and the second one was measured 29.9±13.2 months after transplantation in men and 33.2±12.1 months in women.

Mean reduction of BMD at frontal lumbar spine was 10.7±5.9% for male and 7.8±8.6% for female. Mean reduction of T value of BMD at frontal lumbar spine was 0.969±0.514 for male and 0.54±0.869 for female (p=0.0429). Mean reduction of BMD at lateral lumbar spine was 14.4±12.8% for male and 12.9±11.3% for female. Mean reduction of T value of BMD at lateral lumbar spine was 2.783±2.247 for male and 1.574±1.391 (p=0.0534), In our analysis, male patients showed significantly decrease of BMD than female patients.

Seventy-nine bone scintigraphies were carried out within one month before and after renal transplantation. Sixty bone scintigrams (76%) showed Tc99m MDP distribution of so-called renal osteodystrophy including 7 patients with the distribution of metabolic disease. Eight-four bone scintigraphies were carried out 63.8±45.9 months after renal transplantation, Sixty-seven bone scintigrams of Tc99m MDP (79.8%) showed normal whole body distribution including 5 cases of abnormal uptake in the hip joints.

We concluded that patients with successful renal transplant showed the improved finding of bone scintigrams, however bone mineral density was reduced especially in male gender.