ABSTRACTS PRESENTADOS AL 11th INTERNATIONAL SYMPOSIUM "RADIONUCLIDES IN NEPHRO-UROLOGY", REALIZADO EN MONTEREY, CALIFORNIA, 13-17 MAYO 2001.

CG Zhang, FZ Kong, QF Hu, Sj Li, H Yang, T. Zhang, BL Li.
Nº 1 Hospital of Shauxi Med. Univ. Taiyuan, China.

In the last few years several studies have indicated that smoking is also a risk factor in the progression of renal disease. The purpose of this study was to observe the effect of smoking on rest and exercise renograms in mild and moderate hypertension. 42 subjects (84 kidneys) were studied. All of them were volunteers who were divided into four groups. Group I consisted with 9 smokers with hypertension (age: 44±11); Group II consisted with 16 non-smokers with hypertension (age: 52±7); Group III is a normal control including 7 smokers (age: 36±13); Group IV is also a normal control including 10 non-smokers (age: 33±13). All subjects have normal BUN, creatinine, ECG and no cardiovascular risk factors. All normal control subjects have no hypertension family history. Tc99m-DTPA imaging (5 mCi) was done upright on a bicycle at rest (R) and during exercise (5 mCi) at 60% maximum predicted heart rate (220-age) for 15 min (EX). Heart rate, blood pressure, ECG were monitored. The results with a significant different are listed on below table.

Note: The results are analyzed by statistic analysis system (SAS). The means with the different letters are significant difference. Because the EX study is no significant difference except GFR the EX results are not listed.

In order to investigate the change of the MTT after EX study the difference between R and EX was divided into 3 groups: prolonged (> 20 sec); shortened (< 20 sec) and no change (within 20 sec). The results are showed below.

Our preliminary results showed that smoking may further damage the renal function in hypertensive and rest and exercise renograms may be a sensitive method for finding early injury of renal function.