|
36. COMPARISION
OF RENAL PHYSIOLOGICAL PARAMETERS FOR Tc99m-MAG3 AND Tc99m-DTPA
INFLUENCED BY HYDRATION STATUS IN NORMAL SUBJECTS.
SH Kim,
YA Chung, EN Kim, IR Yoo, YH Park, SY Lee, HS Sohn, SK Chung
Department
of Nuclear Medicine, The Catholic University of Korea, Seoul,
Korea
sghnk@cmc.cuk.ac.kr
We undertook this study to evaluate the influence of hydration
state upon renogram curves and functional parameters, and to
compare the results between tubular and glomerular agents. The
study population was 22 kidneys of 11 volunteers with no history
of hypertension, diabetes mellitus or renal disease and with
normal serum creatinine level. They were 6 men and 5 women aged
from 24 to 48 yrs (mean=33.4 yrs). Radionuclide renographies
were obtained with 185 MBq of Tc99m-MAG3 and Tc99m-DTPA after
dehydration (urine s.g. > 1.020) and adequate hydration in
each subject. Renograms were generated from whole-kidney (WK)
and cortical (C) regions of interest (ROI). We analyzed renogram
patterns, time to peak activity (Tmax), time from peak activity
to half peak (T1/2), renal activities at 20 mins/3 mins (K20/3),
mean transit time (MTT), and glomerular filtration rate (GRF
with Tc99m-DTPA) and tubular extraction rate (TER with Tc99m-MAG3).
After dehydration, 7 kidneys with DTPA and 5 kidneys with MAG3
showed marked fluctuations on the renogram curve with WK ROI,
which were partially offset by C ROI. The mean of physiological
parameters of each kidney on MAG3 and DTPA renographies are
shown in Table I.
Table
I
H= Hydration state, D = Dehydration state, *p<0.01. †p<0.05:vs
hydration state
Dehydration
can bring about abnormal curve pattern and prolong tubular transit
parameters on the renogram with WK ROI, which can be partially
offset by C ROI. However, renal clearance is not affected by
hydration status. There are no differences between MAG3 and
DTPA parameters according to hydration status.
|
