ABSTRACTS PRESENTADOS AL 11th INTERNATIONAL SYMPOSIUM "RADIONUCLIDES IN NEPHRO-UROLOGY", REALIZADO EN MONTEREY, CALIFORNIA, 13-17 MAYO 2001.

29. SERUM ß2-MICROGLOBULIN AS MARKER OF GFR

C. Bianchi, C. Consani, C. Donadio, G. Tramonti, P. Lorusso, * G. Rossi.

Dept. Int. Med. Div. of Nephrol., Univ. of Pisa,
* Epidemiologia e Biostatistica, Fisiologia Clinica, Pisa, Italia.

AIM: To compare serum creatinine (Cr) and serum 2-microglobulin (ß2M) as marker of GFR.

PATIENTS: 178 adult pts with various chronic kidney diseases, 88 M and 90 F, aged 16-83 yrs (mean 55), body weight 43-108 kg (mean 68.5), with normal muscle mass and nutritional status, participated in this study. Their renal function ranged from normality to advanced renal failure (Cr 0.40-13.30 mg/dl), mean 1.77).

METHODS: Cr has been measured by autoanalyzer,ß2M by RIA and GFR by the bladder cumulative method using Tc99m-DTPA as glomerular tracer. GFR has been adjusted to a body surface area of 1.73 m2.

RESULTS: The results are reported in Tables I and II

Table I -Serum Cr and serum ß2M in groups with decreasing GFR (mean ±SD)

*p<0.05 º p<0.001 with respect to group with GFR>100, Student's test

Table II - Percent increase of serum Cr and serum ß2M with decreasing GFR
GFR

In pts with impaired renal function ß2M increases and more than Cr.

A linear relationship was observed between ß2M and Cr (y= 2.170 x+0.317, r=0.890, p<0.001) as well as between GFR and reciprocals of Cr (y= 0.009x+0.304, r=0.792, p<0.001) and ß2M (y=0.005x+0.089, r=0.773, p<0.001).

CONCLUSIONS: These results indicate that ß2M is a reliable marker of GFR, alternative or complementary to Cr. Its clinical interest is higher in patients with minor degrees of renal impairment .