ABSTRACTS PRESENTADOS AL 11th INTERNATIONAL SYMPOSIUM "RADIONUCLIDES IN NEPHRO-UROLOGY", REALIZADO EN MONTEREY, CALIFORNIA, 13-17 MAYO 2001.
16. EXERCISE RENOGRAPHY: THE RESULTS APPEAR TO BE MISSING LINK NEEDED TO EXPLAIN THE ORIGIN OF THE ISCHEMIC NEPHRON IN THE "HYPOTHESIS OF NEPHRON HETEROGENEITY WITH DISCORDANT RENIN SECRETION".
John H. Clorius, Kooperationseinheit, Deutsches Krebsforschungszentrum Heidelberg, Germany.
A
renal functional disturbance associated with hypertensive disease
has been investigated primarily with the exercise renogram. Considerable
data have accumulated which strongly suggest that the investigated
renal functional disturbance is specific for essential hypertension
(EH). The results of exercise renography, standing renography and
clearance determinations at rest and during exercise can not be explained
without drawing on the "Hypothesis of Nephron Heterogeneity"
formulated by Laragh, Sealey and associates (1). The hypothesis is
based on the morphology of the kidney in EH, and explains the inappropriately
high renin secretion, salt retention, and the resulting elevation
of blood pressure. Available evidence from our functional studies
will be presented to support the postulate that the hypertensive kidney
must have two functionally separate nephron population: ischemic and
hyperfiltering nephrons as described in the hypothesis. Furthermore,
individual nephrons must be able to fluctuate from one nephron population
to the other, since the size of the dysregulating population varies
over time. Initial data will also be shown which suggest that the
studied disturbance should be considered capable of initiating the
morphologic restructuring of the population of ischemic nephrons,
described in the hypothesis.
Cit: Sealey JE, Blumenfeld JD, Bell GM, Pecker MS, Sommers SC, Lagarh JH. On the renal basis for ressential hypertention:Nephron heterogeneity.... J Hypertens 1988; 10:763-777.
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